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David H Kirn Selected Research

dl1520 (ONYX-015)

11/2007Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963.
8/2005The use of oncolytic vaccinia viruses in the treatment of cancer: a new role for an old ally?
2/2003A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma.
7/2002Liver-directed viral therapy for cancer p53-targeted adenoviruses and beyond.
2/2002Oncolytic activity of the E1B-55 kDa-deleted adenovirus ONYX-015 is independent of cellular p53 status in human malignant glioma xenografts.

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David H Kirn Research Topics

Disease

35Neoplasms (Cancer)
01/2021 - 02/2002
8Vaccinia
08/2015 - 08/2004
5Infections
01/2021 - 03/2003
5Hepatocellular Carcinoma (Hepatoma)
01/2015 - 09/2008
3Neoplasm Metastasis (Metastasis)
01/2018 - 02/2003
3Necrosis
05/2013 - 07/2004
3Carcinoma (Carcinomatosis)
06/2008 - 11/2007
2Colorectal Neoplasms (Colorectal Cancer)
04/2010 - 07/2002
1Neuroendocrine Tumors (Neuroendocrine Tumor)
01/2021
1Liver Neoplasms (Liver Cancer)
01/2015
1Hypoxia (Hypoxemia)
02/2013
1Virus Diseases (Viral Diseases)
06/2010
1Head and Neck Neoplasms (Head and Neck Cancer)
06/2009
1Ovarian Neoplasms (Ovarian Cancer)
05/2008
1Coinfection
05/2006
1Carcinogenesis
07/2004
1Mesothelioma
07/2004
1Pancreatic Neoplasms (Pancreatic Cancer)
02/2003
1Pancreatitis
02/2003
1Adenocarcinoma
02/2003
1Sepsis (Septicemia)
02/2003
1Glioma (Gliomas)
02/2002

Drug/Important Bio-Agent (IBA)

13Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
01/2021 - 11/2007
5CytokinesIBA
01/2021 - 07/2004
5dl1520 (ONYX-015)IBA
11/2007 - 02/2002
4Thymidine KinaseIBA
01/2021 - 11/2007
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2015 - 06/2011
3ErbB Receptors (EGF Receptor)IBA
04/2012 - 06/2008
3Biological ProductsIBA
08/2011 - 02/2003
2AntigensIBA
03/2015 - 05/2013
2Smallpox Vaccine (Vaccine, Smallpox)FDA Link
01/2015 - 07/2012
2Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
02/2013 - 05/2006
2Colony-Stimulating Factors (Colony Stimulating Factor)IBA
07/2012 - 09/2008
2Antineoplastic Agents (Antineoplastics)IBA
06/2010 - 09/2008
1CD8 AntigensIBA
01/2021
1Interleukin-2 (IL2)IBA
01/2021
1LigandsIBA
01/2021
1ChemokinesIBA
01/2021
1Death Domain ReceptorsIBA
01/2021
1Fas Ligand Protein (Fas Ligand)IBA
01/2021
1Granzymes (Granzyme)IBA
01/2021
1Sunitinib (Sutent)FDA Link
01/2018
1Granulocyte Colony-Stimulating Factor (G-CSF)IBA
08/2015
1N-acetyltalosaminuronic acid (NAT)IBA
01/2015
1Neoplasm Antigens (Tumor Antigens)IBA
05/2013
1Complement System Proteins (Complement)IBA
05/2013
1N 30IBA
03/2013
1GalactosidasesIBA
02/2013
1Interferon Type IIBA
04/2012
1Peptides (Polypeptides)IBA
08/2011
1raf KinasesIBA
06/2011
1Sorafenib (BAY 43-9006)FDA Link
06/2011
1Small Molecule LibrariesIBA
06/2010
1Paclitaxel (Taxol)FDA LinkGeneric
05/2008
1Carboplatin (JM8)FDA LinkGeneric
05/2008
1interferon gamma-1bFDA Link
05/2008
1Neutralizing AntibodiesIBA
04/2008
1Lipid Bilayers (Lipid Bilayer)IBA
04/2008
1Proteins (Proteins, Gene)FDA Link
04/2008
1anticomplementIBA
04/2008
1Interferon-betaIBA
12/2007
1Antiviral Agents (Antivirals)IBA
12/2007
1vaccinia growth factorIBA
11/2007
1E2F Transcription FactorsIBA
11/2007
1VaccinesIBA
08/2005
1erioniteIBA
07/2004
1AgarIBA
07/2004
1AsbestosIBA
07/2004
1Interleukin-1beta (Interleukin 1 beta)IBA
07/2004
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2004
1Anti-Bacterial Agents (Antibiotics)IBA
02/2003
1GemcitabineFDA Link
02/2003
1Lipase (Acid Lipase)FDA Link
02/2003
1Pharmaceutical PreparationsIBA
02/2002

Therapy/Procedure

18Therapeutics
01/2021 - 07/2002
4Oncolytic Virotherapy
06/2010 - 08/2004
3Intravenous Administration
01/2021 - 11/2007
3Injections
03/2015 - 02/2002
2Immunotherapy
08/2015 - 03/2013
2Intravenous Infusions
02/2013 - 08/2011
2Drug Therapy (Chemotherapy)
04/2010 - 03/2003
1Intravenous Injections
01/2018
1Radiofrequency Ablation
01/2015
1Radiotherapy
03/2003
1Aftercare (After-Treatment)
02/2002